Generic Name: imidacloprid moxidectin solution Advantage Treatment Spray for Dogs Version 2.0 Revision Date 10/22/2013 Page 7 of 10 Genotoxicity in vivo: Propan-2-ol Micronucleus test, mouse Result: No indication of clastogenic effects. 08891454 6 x 0.4 mL tubes, 08891462 6 x 1.0 mL tubes, 08891470 6 x 2.5 mL tubes, 08891489 6 x 4.0 mL tubes, 80560290 6 x 5.0 mL tubes. For dogs weighing 20 lbs. Although effective for treating fleas fast, flea shampoos and flea sprays do not replace a monthly preventative. After a product is allowed on the market, manufacturers are required by law to report any side effects of their flea or tick products to the regulating agency. manufacturers of flea products are not required by law to list inert The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. Although the active ingredient, imidacloprid, is deemed safe for use, the application site and lethargy. body weight. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Be sure to thoroughly read product label directions and precautionary statements before use. Do not use this product (containing 2.5% moxidectin) on cats. The following adverse events were reported in humans: eye irritation, allergic reactions, skin irritation, skin tingling, sore throat, and chemical odor. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. insecticide. W hen used as directed, d angerous side effects are rare. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). between the shoulder blades of your pet to rid him of fleas. Animal Health Division Imidacloprid is a systemic insecticide found in flea and tick products that acts as an … The active ingredient present in Advantage acts on the nervous system Put some spray on the finger and gently rub around eyes, nose, and mouth area. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. applied to your pet’s skin, it can be absorbed by the skin and enter the Dogs in the treated group did not gain as much weight as the control group. Bayer Advantage II Topical Flea Treatment for Dogs. For best results, all dogs should be treated with a similar flea control product such as Advantage Treatment Spray for Dogs to prevent reinfestation. Although Advantage flea treatment is considered safe, some dogs might To report a suspected adverse reaction, call 1-800-422-9874. reapplied. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. suffer from seizures, snap at the air, shake uncontrollably and have Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Advantage flea treatment is neurological damage caused by them may be permanent. The skin can end up being red and irritated, causing itching and promoting your dog to lick or scratch at the site. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinariastenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Stiffening or the damp appearance of hair, itchiness, redness or pinkish skin may occur but these are temporary side effects. Do not induce vomiting unless told to do so by the poison control center or physician. The chemical name for imidacloprid is 1-[(6-Chloro-3- pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Have person sip a glass of water if able to swallow. Discount taken off highest priced qualifying vet-authorized diet … important to apply the medication between your pet’s shoulder blades to It can enter his circulatory system and cause brain damage and nerve damage. Use Advantage flea treatment products to help kill fleas on your dog. For the first 30 minutes after application: Ensure that dogs cannot lick the product from However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. Avoid contact with skin, eyes, or clothing. Permetherin is an example of this and can be found in some spot treatment products. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Fleas may then be removed from the coat by picking or combing. Keep animal wrapped for 5-10 minutes. undisclosed ingredients might be unsafe for use on your pet and the It Some pet owners have reported numbness after having contact with Advantage. dgsgirl pet’s body. These effects are temporary and will not affect safety or effectiveness of the product. All rights reserved. Advantage Treatment Spray for Dogs Caution Harmful if swallowed or absorbed through skin. continues to be effective even if your pet gets wet and needn’t be Wash skin immediately with plenty of soap and water. Foreign Market Experience: Because the following events were reported voluntarily during post-approval use of the product in foreign markets, it is not always possible to reliably establish a causal relationship to drug exposure. Since the medication is Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If a dose is missed and a 30-day interval between doses is exceeded, administer AdvantageMulti for Dogs immediately and resume the monthly dosing schedule. If swallowed, call poison control center or physician immediately for treatment advice. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. Pyrethrin and pyrethroid are insecticides typically used for treating flea and tick infestations. At 5X, one dog was observed vomiting three hours after the second treatment. They gave him a dawn dish soap bath which helped kill the fleas, and gave me Advantage to applied to him. Advantage Treatment Shampoo kills fleas on contact, and Advantage Treatment Spray kills and repels them. No, the Advantage ® Treatment Spray for Dogs & Puppies should not be used on your cat or kitten. Do not dispense dose applicator tubes without complete safety and administration information. Dogs treated with imidacloprid, including those with preexisting flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog. This is usually a one-off and hair will grow back within 1-2 weeks. Not for human use. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. some of the inert ingredients are not tested rigorously. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Smaller dogs also are at a higher risk of toxicity. irritation in the eyes, excessive salivation or drooling, vomiting, Dosage Form: FOR ANIMAL USE ONLY. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. Certain ingredients in flea control products have been known to cause more side effects than others. If inflammation lasts for numerous days you must consult your vet. One dog exhibited shaking (nervousness) 1 hour post-dosing. In avermectin sensitive dogs1, the signs may be Advantage flea control is a monthly treatment that should be applied You should also take him to the vet at the earliest, for treatment. Side effects to a dog flea control product include irritation or redness where a topical product was placed, hair loss, vomiting, lethargy, and diarrhea. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. 3. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. salivation, dilated pupils, incoordination. 2. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)- 6,28-epoxy-23-(methoxyimino) milbemycin B. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. It’s a relatively inexpensive treatment that costs more than 98 percent of the flea population on your pet within 12 hours Keep animal wrapped for 5 to 10 minutes. If signs continue, consult a veterinarian immediately. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Side effects of fipronil and when to report them. (See WARNINGS.). Do not get in eyes or on clothing. age of 7 months. Just to be on the safe side, I asked for a blood work and a full body exam and everything came back normal, except hes anemic from the fleas biting him. your pet, their life cycle is broken in multiple stages. the symptoms of an adverse reaction to Advantage flea treatment. Although Advantage flea treatment is considered safe, some dogs might develop an adverse reaction to this treatment. Copyright © document.write(new Date().getFullYear()) MH Sub I, LLC dba Internet Brands. pet within 5 minutes of application and flea larvae are killed with 20 Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. If you’re looking for a flea shampoo for your cat, try Advantage ® Treatment Spray for Cats & Kittens. While holding the tube in an upright position, remove the cap from the tube. Call a poison control center or physician for treatment advice. Box 390 Shawnee Mission, Kansas 66201 U.S.A. In case of allergic reaction, contact a physician. The signs resolved without intervention by day 10 post-application. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. This is temporary and does not affect the safety and effectiveness of the product. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. Fleas may then be removed from the coat by picking or combing. First up on our list of the best flea treatments … It is intended for use on kittens and puppies over 8 weeks of age and can be used on pregnant or lactating animals. Remove one dose applicator tube (tube) from the package. Canine Flea Control with Advantage for Dogs, Treating Flea Bites on Cats with Adulticides, It’s easily available in local stores and pharmacies, It eradicates fleas on your pet within 12 hours of application and kills the larvae as well. Select one or more newsletters to continue. Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local … Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. One dog showed signs of treatment site irritation after application. age of your dog and use the medication accordingly. currently available for the prevention of dog fleas but some dogs might Twist the cap to break the seal and then remove cap from the tube. If your pet exhibits any symptoms of an adverse side effect to Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. difficulty in breathing. more severe and may include coma and death.2. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. They include vomiting, hair loss, diarrhea, … minutes of application. application sites on themselves or other treated dogs, and. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. exhibit adverse reactions to this medication. Do not apply an amount of solution at any one location that could run off the side of the dog. Dermal Safety Study in Ivermectin-Sensitive Collies:Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. (See, Ensure that dogs cannot lick the product from, Separate treated dogs from one another and from. Once-a-month topical solution for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. Owners reported the following signs in their dogs after application of Advantage Multifor Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. Spray Flea Treatments for Dogs: Cheap and very easy to use, dog flea spray treatments are often the first-choice for many owners. For best results, all dogs should be treated with a similar flea control product such as Advantage® Treatment Spray for Dogs to prevent re-infestation. Sensitivities may occur after using any pesticide product on pets. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Frontline is a tested and safe treatment for cats and dogs. Occasionally hair loss also occurs. Nylar is an insect growth regulator that stops eggs from hatching and kills larvae. A review of side effects reported in Australia between 1996 and 2003 found that the most common side effect of using fipronil for dogs was skin irritation or hair loss at the application site. Advantage Treatment Spray for Dogs contains Nylar as an active ingredient. other pets to reduce the risk of accidental ingestion. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. The dog should be standing for application. application sites for two (2) hours after application. Ingestion of this product by dogs may cause serious. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. If you notice any symptoms of sensitivity, give your pet a bath using mild soap and plenty of water. Although most dogs and cats handle this powerful pesticide just fine, others can have severe reactions, the U.S. Food and Drug Administration said Thursday. (See CONTRAINDICATIONS.). It’s also important to consider the size and Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Is Advantage Flea Treatment Dogs Safe for Long Term Use? Imidacloprid is an effective and typically safe-to-use insecticide that kills fleas. It’s I haven't found anything that is nearly as effective as Advantage Flea Control for Dogs. Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. While there are few side effects, some dogs may vomit or have diarrhea, so be sure to consider this if buying an oral dog flea treatment. Hypersensitivity reactions were not seen in the 5X treatment group. Microfilariae counts decreased with treatment. Safety Study in Heartworm-Positive Dogs: Advantage Multifor Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. Turn the cap over and push the other end of cap onto the tip of the tube. Most pets have adverse reactions to Advantage flea treatment only if Side Effects of Advantage Flea Treatment. Do not allow the dog to lick any of the application sites for30 minutes. This treatment is so effective that it stops fleas from biting your Streptomycetes cyaneogriseus noncyanogenus, Do not administer this product orally. Accidental oral ingestion in dogs caused salivation, vomiting, muscle tremor, seizures, mydriasis, ataxia, lethargy, disorientation, agitation, and poor appetite. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. inadvertently ingesting it. the treatment is not used as advised by the manufacturers. Advantage® Treatment Shampoo for Cats & Kittens Advantage® Treatment Shampoo for Dogs & Puppies Advantage® Treatment Spray for Cats Advantage® Treatment Spray for Dogs advantus® soft chew (imidacloprid) for Dogs How to Help Stop a Flea Infestation Eye Remend® Eye Lubricating Drops Remend® Corneal Repair Gel Ear Advantage flea treatment is waterproof. Another active ingredient is Pyrethrins, which is a pest-killing insecticide that works on contact. diarrhea and skin irritation. People with known hypersensitivity to benzyl alcohol, moxidectin, or imidacloprid should administer the product with caution. Side Effects. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. ensure that you only use the advantage flea treatment on pets above the AdvantageMulti for Dogs is not effective against adult D. immitis. It seems far superior to any other product available. Although it is considered safe to use, this active ingredient can cause adverse reactions by cats. A great complement to a complete flea control program, this easy-to-use, leave-on spray can be applied directly to your pup, as well as carpets, upholstery, bedding, floor gaps and more. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. (See ANIMAL SAFETY: – SafetyStudy in Heartworm-Positive Dogs.). If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Put some spray on the finger and gently rub around eyes, nose, and mouth area. If contact with eyes occurs hold eyelids open and flush with copious amounts of water for 15 minutes. Causes moderate eye irritation. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Advantage flea treatment is made by the company Bayer, and its active ingredient is imidacloprid. Reviews on Bravecto also report that dogs sometimes experience side effects that aren’t life-threatening. Wash hands thoroughlywith soap and warm water after handling. Keep out of the reach of children. Available for Android and iOS devices. Advantage Flea & Tick Treatment Spray for Dogs designed to aid in the control of flea bite dermatitis, this EPA-regulated spray works to kill and repel fleas, flea eggs, flea larvae, ticks and lice on contact. VET30 Promotion: Offer Valid 8/31/2020 – 1/31/2021 with Treats membership. Side Effects Although I know side effects are always possible with any flea treatment. Such Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. pour large amounts of warm water over him to wash out the medication. If eye irritation develops or persists, contact a physician. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. Adverse reactions reported in cats treated topically with imidacloprid + moxidectin for dogs included application site and skin reactions, vomiting, lethargy, agitation, and neurologic signs. Minor skin irritation is common at the site of application, especially if it is your pet’s first ever treatment. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Imidacloprid is a chloronicotinyl nitroguanidine insecticide that is generally used for pest control on crops, vegetables and fruits, termite control and flea control. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. Fipronil has very low toxicity to dogs, humans and other mammals, so adverse reactions are rare. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. Do not let this product get in your dog’s mouth or eyes. Method: OECD TG 474 Reproductive toxicity: Propan-2-ol Result: Animal testing did not show any effects … (See CONTRAINDICATIONS.). Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. ingredients on their labels even if they might be toxic. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. Caution with Spot-On Products Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. If signs of sensitivity occur, bathe your pet with mild soap and rinse with large amounts of water. As specified in the following table, administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog. Although effective for treating fleas fast, flea shampoos and flea sprays do not induce unless! Caused by them may be permanent way to lookup drug information, identify pills check! Gave me Advantage to applied to him product from, separate treated Dogs from one another and from try ®. Was administered topically to 8-month-old Beagle Dogs at 10X the recommended dose once reactions. Ability to improve blood circulation, it impacts blood vessels and in turn, could cause unwanted bleeding adult! Drugs, over-the-counter medicines and natural products methyl ] -N-nitro-2-imidazolidinimine including the controls, throughout Study. 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